Tracking Coronavirus Vaccine Developments

p 0 The Proximal Origin Of SARS-CoV-2 p 1 Tracking Down Covid-19 Origin loads slowly p 3 Tracking Coronavirus Investigations p 4 Tracking Variants of Concern p 5 World Health Insists On Lab Leak Investigation

Warp Speed

- With Wuhan virus genetic code in hand, scientists begin work on a vaccine - Jan 24, 2020 page

YOUTUBE jEZCwBw1R2A 3 doses of Pfizer vaccine to protect against Omicron

Variants

- Variants of Concern page

Gilead Sciences

Coronaviruses SARS emerged from bats in 2013 to kill without great transmissibility (WHO) page

SARS emerged shortly after MERS (camels) in 2011 and H1N1 in 2009. Thus began NIH funding to predict future viruses. That somehow lead to the SARS2 pandemic.

As we research--Tracking Down Covid-19 Origin--we find vaccine development also driven by high risk 'gain of function' experiments. Research that in 2014 was prohibited by Obama, because it was deemed to be dual use research of concern page

Apparently research into SARS and MERS also spurred other drug developments. Most famously, Remdesivir aka Gilead Sciences GS-5734. Donald Trump took it with emergency authorization by the FDA. It is credited with his rapid recovery from Covid-19 at Walter Reed National Military Medical Center.

It is also important to note that the US National Institutes of Health (NIH) and Moderna entered into an agreement in 2019 to co-develop coronavirus vaccines; however, this was before the identification and spread of SARS-CoV-2.

Intertwined scientific interests that we find requires review of the totality of competing interests. page Ironic Twist: Trump halted EcoHealth research key to Remdesivir he took at Walter Reed to save his life page

News

- Texas mother opens up after 5-month-old son contracted COVID from a vaccinated family member page - Why some double vaccinated people are dying of Covid-19 page - One Vaccine Makes More Antibodies Than Another. Does it Matter? page - The Proliferation of COVID Variants - Bret Weinstein video , bio

Vaccine Timeline

- 2017: Antiviral GS-5734 inhibits page - 2019 Sep: DHS EHA Pathogens/Vax grant pge - 2019 Dec 12: NIAID-Moderna Covid vaccine transfer agreement Ref No. 2015-33448 pdf - 2020 Jan 30: Gilead offers experimental coronavirus drug page - 2020 Feb 24: Yusen Zhou files patent then dies page , page - 2020 Feb 28: - EcoHealth Alliance Elects Intellectual Property Attorney Geoffrey Potter to its Board of Directors page - 2020 March 16: Redacted emails WHO trials FDA, HCQ, Moderna page - 2020 April 27: NIH study result same day a negative study from China of Remdesivir page - ClinicalTrials.gov site

NIAID patents

Federal scientists at NIH have helped design and test mRNA-1273—a vaccine candidate developed in partnership with Moderna.

The U.S. government appears to jointly own Moderna's coronavirus vaccine patents.

U.S. Application No. 62/972,886 "component of 2019-nCoV vaccine". page

U.S. Application No. 16/344,774 “Prefusion Coronavirus Spike Proteins and Their Use".

Two NIH-Moderna Agreements that appear relevant to a COVID-19 vaccine candidate have redacted information page

mRNA vaccines — a new era in vaccinology page

Prophylaxis

Similar to SARS-CoV and MERS-CoV, SARS-CoV-2 is an enveloped, single stranded, and positive (+)-sense RNA virus, belonging to the beta-CoV general in the family Coronaviridae. The genome of this emerging pathogenic human CoV encodes four major structural proteins – spike (S), envelope (E), membrane (M), and nucleocapsid (N) – and approximately 16 nonstructural proteins (nsp1–16) and five to eight accessory proteins. Among them, the S protein plays an essential role in viral attachment, fusion, entry, and transmission pdf

Secret Vaccine Contracts

- Operation Warp Speed is using a CIA-linked Contractor to keep Covid-19 vaccine contracts secret page

Clinical Trials

Treating long-haul Covid-19

YOUTUBE 85aPvvpiAnM Treating Long Covid Cytokine Storm. Stanford Medicine (see 51 mins)

- Cytokine storm syndrome trial page - Cytokine storm syndrome - Stanford video - ACE2 coding variants in different populations p - Precision medicine for every ethnicity page

EcoHealth Alliance

Peter Daszak, > “We need to increase public understanding of the need for medical countermeasures such as a pan coronavirus vaccine. A key driver is the media and the economics will follow the hype. Investors will respond if they see profit at the end of the process” (02/12/2016) page

- Pentagon gave millions to EcoHealth Alliance for weapons research program page - EHA elects IP attorney Geoffrey Potter to BOD page - IC Postdoctoral Research pg pg - EHA under scrutiny, India, BMGF, One Health pg

An April 2020 email on progress reports from Ecohealth, Daszak mentions. We are concerned... >"colleagues in Wuhan, who are working at the leading edge to design vaccines and drugs that could help us fight this new threat in future years. It is quite remarkable that of the 5 vaccine candidates listed by WHO that are already in human trials, 3 have been developed in China." Tracking Coronavirus Investigations - The Intercept: NIH-EHA paperwork gaps & contradictions pg

Pfizer

- Pfizer's CEO on preliminary COVID-19 vaccine data (Judy Woodruff, PBS) video

- Durability of the Pfizer vaccine is not very long page

- PFIZERLEAK: Pfizer Contract Leaks page

Zoetis

> Zoetis produces many livestock, dog and cat vaccines. For pets, it makes vaccines for canine infectious respiratory disease, feline leukemia virus and others. The company began its work on an animal vaccine in February at the start of the pandemic. - Zoetis Inc. IPO info 2013 page - Zoetis (animal vaccines). Parsippany, NJ site - Zoetis originally animal division of Pfizer page - Embattled Zoetis courts investors as ... page - K Smith ~ 9 years EHA now Zoetis pg , pg - Zoetis paid EHA $255,000 in license income EHA-Form990-FY15 (p19/43) df - End of Pandemic Era ~ One Health Recap pdf - Experimental non-human COVID-19 vax page - Zoetis CEO Juan Alaix left 3 Oct 2019 pg , pg - IFAH is headed up by Juan Alaix, CEO of Zoetis, see OneHealth inset pdf - Uncertain linkages ... twit - COVID-19 animal vaccines easy to make pg - Zoetis veterinary COVID vaccine for zoos page - Chimp sanctuary set to give Zoetis vax page - Zoetis vax uses synthetic spike proteins page - 1993 Pfizer patent WO1993023422 +30 yrs pg - Zoetis and One Health page - Zoetis.CTED page , pdf - Lawsuit against Zoetis Hendra horse vaccine p - Antibiotics to Vaccines - Zoetis notes - EHA, Nat'l Wildlife Health Ctr, DARPA 2018 pg - Zoetis seeking licensing from US Dept of Ag pg - Zoetis rolling out experimental spike sub-unit covid19 vaccine for zoos page - Experimental monoclonal antibody therapy, from a supply that could not be used on people pg

Notes - Zoetis and Regeneron monoclonal antibody pg

- The Intercept has linkage between EcoHealth and Abaxis Vetscan VS2 acquired by Zoetis in 2018. Maybe EHA provided the IP or uses VS2 to test blood in the field (2 drops needed)page - VIDO Intervac 2015-2016 - Zoetis pdf , pg

Medgene Labs

Medgene Labs [2014] site > Medgene Labs monitors the production environment for new viruses, continuously updates its virus sequence library and vaccine construct bank to rapidly counter production health risks, and serologically monitors vaccinated animals for an antibody response. - COVID-19 vaccine for pets production news

OneHealth Vaccine

Nipah conference proceedings Dec 2019, 9-10 pdf - $1.2 billion for Global Virome Project page - EcoHealth and One Health page - EcoHealth and Opportunities for Defense... pdf - EHA USAMRIID page - Mapping the incomplete integration pdf - 60 minutes page - One Health Commission - Synergizing pdf - The GVP: Bringing an end to pandemics pdf

Global Virome Project

Dennis Carroll GVP Head x-USAID x-PREDICT pg

Wuhan Keqian Biology Ltd

- kqbio.com site - SARS-CoV2 vaccine approved page - scholar

Corona Virus Patent

- Application in July 23, 2015 (Pirbright) Patent History Patent number: 10130701 socialgrep

ARCoV

- Thermostable mRNA vaccine against C9 pub - Late stage trial mrna vaccine candidate page - Walvax site - Suzhou Abogen Biosciences site - AMS site

Remdesivir

When Denison's team put the drug into a petri dish with the mouse hepatitis coronavirus, it showed "tremendous" success. This sparked a collaboration with researchers at still more institutions — including Timothy Sheahan at the University of North Carolina at Chapel Hill pg

- Gilead offers experimental COV-19 drug page - US Gov’s apparent co-ownership of patents protecting Remdesivir pdf - Nurith Aizenman, NPR vax news page ,tweet

- Yusen Zhou died after filling patent page - Shibo Jiang 2004 co-author with Zhou page - Patents Shibo Jiang page

- WIV vaccine patent filed Jan 19, 2020 page

Moderna

- Flagship Pioneering, behind Moderna page - WHAT?! Fauci partnered with Moderna on vaccine | Dr. Maria Ryan video - BB Biotech page

J&J

- J&J partners with EHA awards $900,000 page - Sr. J&J manger added to EHA board page - EHA adds recently at J&J attorney to BOD pge - Marianne De Backer, EHA Board pg ,LI , pg

Ligand Pharmaceuticals

The plan comes a month after Ligand announced plans to break out the unit into a new company, which focuses on using transgenic animals to generate human antibodies. pg , pg > Peter Daszak on December 9, 2019 (28:17): Some of them get into human cells in the lab, some of them can cause SARS disease in humanized mice models and are untreatable with therapeutic monoclonals, and you cannot vaccinate against them twt

US Patents

Mouse-adapted SARS-CoV-2 viruses and methods of use thereof US patent 11225508 - Serial passage with humanized-mice twt , full - A mouse-adapted sars-cov-2 induces acute lung injury and mortality in std laboratory mice pg - "The transgenic mice expressing the human ACE2 protein (hACE2) under mixed genetic backgrounds were obtained from Ralph S. Baric’s lab" pg

Novavax

- MERS vaccine (Novavax et al) pdf - EHA et al page - JPEO-CRBND-EB - Dr Angela Rasmussen - The Long Shot ... pg

Geneva Foundation

- USAMRIID concerned about duality page - Vaccine without a cold chain reqm't patents - @Genevausa page

Convalescent Plasma

- Convalescent plasma page page - Coronaviruses in bats in Mexico page - Guang Jian-Zhu page page - 188-112: hkrrr | 230-233: krrr page - 40S ribosomal protein S6 page - Heatbio (Lanying Du) page - WHO backs blood transfusions from Ebola survivors as treatment 2014 page - Wuhan convalescent plasma treatment page

NYBC LFKRI

- Grants: Du / Daszak / Jiang MERS NY page - Lanying Du, allegedly Yusen Zhou’s wife page - NYBC plans BLS 3 lab (cord blood) page - Environment pdf - NYBC LFKRI areas of interest page - NYBC Milstein is largest cord blood page - NYBC leadership page - Vaccine: Wolf, Dasak, Du page - Biodefense page - Biohazard FOIA pdf - Jonathan Epstein, EHA, Wayback web page - USTRK the Fang Li email dump pdf - Receptor Recognition Mechanisms pub - Primate research in Liberia page - NYBC RBD-based subunit vaccine pg - Zhou Yusen, filed patent Feb 24 died in May pg

Lanying Du

- Dr. Lanying Du was in AMMS (PLA) with her husband Dr. Yusen Zhou, then got PhD in the University of HK (Supervisors: Drs. Bojian Zheng & Kwok-Yung Yuen). Later Du moved to NY Blood Center working with Dr. Shibo Jiang. Zheng & Jiang also works with PLA. All of them are SARS experts twitter , twitter

Immunotherapy

- Native Human Immunotherapy (Sab Bio)page - COVID-19 drug repurposing research page - Avoiding pitfalls in a COVID-19 vaccine page

Vaccine Discovery

- The vaccine origin timeline (classified) page - Dr Rasmussen to look at vax at VIDO page - Flagship Pioneering, behind Moderna page - Nurith Aizenman, NPR vax news page ,tweet - Pipeline for coronaviruses like SARS page - WHO R&D Blueprint COVID-19 Vax pdf

Vaccine Funding

- NIAID issued $87M to 10 for CREID page

ARA

What we do (funded EHA 2014 - 2019) page

Zika Patent

- Porcupine Spike protein AAK38656.1 page region_name="Corona_S1" - Identification of SC2 Viral Envelope page

Virus Transfers

Interface between Dr. Qiu and Wuhan, China is a highly suspicious prority page

Dr. Xiangguo Qiu, her husband Keding Cheng and her students from China were removed from Canada's only level-4 lab over what's described as a possible "policy breach." > Amir Attaran, professor in the Faculty of Law and the School of Epidemiology and Public Health at the University of Ottawa, is concerned about the shipment of dangerous viruses sent from Canada's only level-4 lab to China. (CBC) page

Research links

- patents.google - Dr. Richard Fleming PhD, MD, JD video - ENF page - Vax and plasma collection MERS-CoV ... page - Dr David Franz anthrax era at EcoHealth page

Roof of the World

- Opening Pandora's Box pdf - Dissertation page

Autophagy

- Berlin bat meeting page

Intelligence

- China emulated US (in unsafe conditions) page - Chinese military 'took over' Wuhan lab page - Five subprojects for vaccine development page - China harvesting DNA from millions of women around the world via pregancy tests video - Dysregulation of brain in severe COVID-19 pge - One Health Recap ~ Vaccine dev is key pdf - Dual use pdf Jon Kevin Billy David - Wellcome Trust at pdf - MHRA page

Lessons Learned

- NYT recommends we move from prediction and gain of function to monitoring and precision medicine page - Precision medicine for every ethnicity page

Automating Search for Variants

Automating has speed-up search for variants pg

Commentary

- Trust science, not scientists page

Questionable

- Twenty-year genetic trail ...page - Sinopharm Group (Wuhan Institute of Biological Products) and Chinese Academy of Sciences (Wuhan Institute of Virology) page - Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction pdf - Hugh Auchincloss page , page - ‘One Health’ becomes a movement . . . page - Nanoparticle platform pdf - State of Hawaii - DoD - testimony pdf - GFRA - Wellcome Trust vax strategies pdf

Pediatric Vaccine

Two doses in children between the ages of two and four, produced disappointing results, prompting the addition of a third dose for all children under five in the trial. Data on the third shot is not expected until March at the earliest page - Prof of Pediatrics (Infectious Diseases) page

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